THE 2-MINUTE RULE FOR BET ON SPORTS

DNA ligases seal five′-PO4 and 3′-OH polynucleotide ends through three nucleotidyl transfer measures involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal structures of DNA ligases bound to nucleotide and nu